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In our latest COVID-19 Focused Discussion, Drs. Aloke Finn and Ron Waksman discuss STEMI and microthrombi in COVID-19 patients. In a paper recently published in Circulation, Dr. Finn and co-authors presented the case of a 43-year-old woman who died of COVID-19 at a hospital during the height of the initial surge of infections in Italy. This case showed the potential for microvascular thrombi to cause acute myocardial infarction in the setting of COVID-19, showing a novel mechanism by which the disease can cause cardiac injury.